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. 2023 Jan 24;18(1):e0279752. doi: 10.1371/journal.pone.0279752

Fig 6. SQFZ reverses constitutive and PI3K pathway-induced cisplatin resistance.

Fig 6

(A) Survival of MDA-MB-231/DDP+M2 cells. Cells were treated with SQFZ (100 μl/mL, 48 h), LY294002 (20 μmol/L, 2 h), IGF-1 (100 ng/mL, 48 h), and the combination of SQFZ (100 μl/mL, 48 h) and IGF-1 (100 ng/mL, 48 h) and subjected to the MTT assay. Values are shown as the means ± SE from three independent experiments. *p < 0.05 as compared to the Control. #p < 0.05 as compared to SQFZ 100 μl/mL alone. (B) Flow cytometry analysis of apoptosis based on Annexin V-FITC/PI binding to MDA-MB-231/DDP+M2 cells treated with SQFZ (100 μl/mL, 48 h), LY294002 (20 μmol/L, 2 h), IGF-1 (100 ng/mL, 48 h), and the combination of SQFZ (100 μl/mL, 48 h) and IGF-1 (100 ng/mL, 48 h).