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Neuronal development progresses through several steps, coinciding with the period of high expression of GluN2B. During the early stages of development, GluN2B levels progressively increase, while GluN2A levels are low (yellow). As neurons mature, GluN2A levels increase and ultimately surpass GluN2B expression (blue). GluN2B has been proposed to play a role in neuronal differentiation, dendrite morphogenesis, synaptogenesis, circuit refinement, and synaptic plasticity.
