Table 1.
Sample characteristics
| Characteristic | No. of patients (%)(n=77) |
gBRCA
Pathogenic (n=26) |
gBRCA
VUS (n=8) |
gBRCA
Wild-type (n=43) |
|---|---|---|---|---|
| Age at diagnosis (yr) | 42 (27–75) | 45.5 (29–74) | 34.5 (28–62) | 39 (27–75) |
| Sex | ||||
| Female | 75 (97.4) | 26 (100) | 8 (100) | 41 (95.3) |
| Male | 2 (2.6) | 0 | 0 | 2 (4.7) |
| Stage at diagnosis | ||||
| DCIS | 2 (2.6) | 0 | 0 | 2 (4.7) |
| I | 9 (11.7) | 6 (23.1) | 0 | 3 (7.0) |
| II | 44 (57.1) | 17 (65.4) | 5 (62.5) | 22 (51.2) |
| III | 12 (15.6) | 2 (7.7) | 0 | 10 (23.3) |
| IV | 10 (13.0) | 1 (3.8) | 3 (37.5) | 6 (13.6) |
| Molecular subtype | ||||
| Hormone receptor+ | 23 (29.9) | 10 (38.6) | 6 (75.0) | 17 (39.5) |
| HER2+ | 17 (22.1) | 5 (19.2) | 2 (25.0) | 10 (23.3) |
| TNBC | 27 (35.1) | 11 (42.3) | 0 | 16 (37.2) |
| Family history | ||||
| Breast/Ovarian cancer patients in 1st degree relatives | 28 (36.4) | 14 (53.8) | 2 (25.0) | 12 (27.9) |
| Breast/Ovarian cancer in 2nd degree relatives | 5 (6.5) | 1 (3.8) | 1 (12.5) | 3 (7.0) |
| Breast/Ovarian cancer in 3rd degree relatives | 2 (2.6) | 0 | 1 (12.5) | 1 (2.3) |
| Any other cancer in 1st, 2nd, or 3rd degree relatives | 14 (18.2) | 3 (11.5) | 0 | 11 (25.6) |
| No family history of cancer | 28 (36.4) | 8 (30.8) | 4 (50.0) | 16 (37.2) |
Values are presented as median (range) or number (%). DCIS, ductal carcinoma in situ; HER2, human epidermal growth factor receptor 2; TNBC, triple-negative breast cancer; VUS, variant of unidentified significance.