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. 2022 Jul 1;55(1):196–218. doi: 10.4143/crt.2022.080

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Copyright © 2023 by the Korean Cancer Association

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 6 — Gut microbiome showing changes in “AOM/DSS and TP addition” and “sex and ORX” criteria. (A–C) The abundance ratio of butyrate-producing bacteria among commensal bacteria. (A) Clostridium indolis (Firmicutes: Clostridia: Clostridiales: Lachnospiraceae: Clostridium_g34). (B) Flintibacter butyricus (Firmicutes: Clostridia: Clostridiales: Ruminococcaceae: Pseudoflavonifractor). (C) Kineothrix alysoides (Firmicutes: Clostridia: Clostridiales: Lachnospiraceae: Kineothrix). (D–F) The abundance ratio of commensal bacteria. (D) Parabacteroides goldsteinii (Bacteroidetes: Bacteroidia: Bacteroidales: Porphyromonadaceae: Parabacteroides). (E) Romboutsia timonensis (Firmicutes: Clostridia: Clostridiales: Peptostreptococcaceae: Romboutsia). (F) Ruminococcus bromii (Firmicutes: Clostridia: Clostridiales: Ruminococcaceae: Ruminococcus_g2). (G–J) The abundance ratio of opportunistic pathogens. (G) Bacteroides caccae (Bacteroidetes: Bacteroidia: Bacteroidales: Bacteroidaceae: Bacteroides). (H) Mucispirillum schaedleri (Deferribacteres: Deferribacteres_c: Deferribacterales: Deferribacteraceae: Mucispirillum). (I) Akkermansia muciniphila (Verrucomicrobia: Verrucomicrobiae: Verrucomicrobiales: Akkermansiaceae: Akkermansia). (J) Bacteroides vulgatus (Bacteroidetes: Bacteroidia: Bacteroidales: Bacteroidaceae: Bacteroides). AOM, azoxymethane; CON, control; DSS, dextran sulfate sodium salt; ORX, orchiectomized; SEM, standard error of the mean; TP, testosterone propionate. Data are expressed as the mean±SEM. Whiskers show the minimum and maximum values. The p-values were calculated from the Mann-Whitney U test for comparison difference between independent two groups. *p < 0.05 for “CON vs. AOM/DSS” or “AOM/DSS vs. AOM/DSS+TP” in female, male, and ORX groups, ^†p < 0.05 for “Female vs. Male”, ^‡p < 0.05 for “Male vs. ORX”, ^§p < 0.05 for “Female vs. ORX” in CON, AOM/DSS, and AOM/DSS+TP subgroups.