Table 3.
Risk factors for mortality in patients with NSCLC assessed by Cox proportional hazards model
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Hazard ratio | 95% CI | p-value | Hazard ratio | 95% CI | p-value | |
| Age | 1.032 | 1.027–1.038 | < 0.001 | 1.019 | 1.012–1.025 | < 0.001 |
|
| ||||||
| Male sex | 1.714 | 1.520–1.933 | < 0.001 | 1.222 | 0.985–1.516 | 0.069 |
|
| ||||||
| Ever-smoker | 1.490 | 1.332–1.667 | < 0.001 | 1.112 | 0.899–1.375 | 0.327 |
|
| ||||||
| BMI | 0.998 | 0.995–1.002 | 0.444 | |||
|
| ||||||
| Performance status | ||||||
|
| ||||||
| 0–1 (ref) | 1.000 | 1.000 | ||||
|
| ||||||
| 2–4 | 3.172 | 2.681–3.753 | < 0.001 | 1.995 | 1.655–2.405 | < 0.001 |
|
| ||||||
| Clinical stage | ||||||
|
| ||||||
| I (ref) | 1.000 | 1.000 | ||||
|
| ||||||
| II | 2.434 | 1.855–3.194 | < 0.001 | 1.530 | 1.084–2.159 | 0.016 |
|
| ||||||
| III | 7.801 | 6.241–9.750 | < 0.001 | 3.263 | 2.407–4.423 | < 0.001 |
|
| ||||||
| IV | 8.574 | 6.836–10.754 | < 0.001 | 3.829 | 2.814–5.211 | < 0.001 |
|
| ||||||
| Histology | ||||||
|
| ||||||
| Adenocarcinoma (ref) | 1.000 | 1.000 | ||||
|
| ||||||
| Squamous cell carcinoma | 1.648 | 1.476–1.841 | < 0.001 | 1.203 | 1.033–1.402 | 0.018 |
|
| ||||||
| Treatment | ||||||
|
| ||||||
| Surgery (ref) | 1.000 | 1.000 | ||||
|
| ||||||
| Non-surgical treatment | 6.889 | 5.708–8.314 | < 0.001 | 3.814 | 2.968–4.902 | < 0.001 |
|
| ||||||
| Best supportive care | 10.232 | 8.399–12.466 | < 0.001 | 5.189 | 3.945–6.826 | < 0.001 |
BMI, body mass index; CI, confidence interval; NSCLC, non smallcell lung cancer.