Table 3.
NTRK fusion-positive samples list confirmed with the TSO 500 assay
| Sample ID | Fusion type | Exon No. of BP | Supporting read count | Inframe/Out-of-frame |
|---|---|---|---|---|
| BN01 | ETV6-NTRK3 | E(5)N(15) | 9 | Inframe |
|
| ||||
| BN03a) | TPR-NTRK1 | T(4)N(10) | 128 | Inframe |
|
| ||||
| BN04 | ETV6-NTRK3 | E(5)N(15) | 24 | Inframe |
| E(5)N(14) | 15 | Intronic fusion | ||
| E(6)N(14) | 17 | Inframe | ||
|
| ||||
| BN07 | TPM3-NTRK1 | T(7)N(10) | 80 | Inframe |
|
| ||||
| BN10a) | HOOK3-NTRK2 | H(13)N(14) | 290 | Inframe |
| H(2)N(14) | 81 | Out-of-frame | ||
| H(6)N(14) | 6 | Inframe | ||
| H(2)N(14) | 71 | Inframe | ||
|
| ||||
| BN11 | TPM3-NTRK1 | T(int7)N(8) | 29 | Intronic fusion |
| T(7)N(10) | 524 | Inframe | ||
|
| ||||
| BN13 | RBPMS-NTRK3 | R(5)N(14) | 939 | Inframe |
|
| ||||
| BN17 | TPM3-NTRK1 | T(7)N(10) | 1,269 | Inframe |
| T(8)N(10) | 346 | Out-of-frame | ||
Exon numbers correspond to NM_002529.4 for NTRK1, exon numbers correspond to NM_006180.6 for NTRK2, exon numbers correspond to NM_001012338.3 for NTRK3. BP, breakpoint; NTRK, neurotrophic receptor tyrosine kinase; TSO, TruSight Oncology.
a)
Genes not in OCA v3.