Table 5.
NTRK fusion transcripts detected from Seraseq, NTRK fusion reference
| Fusion Supporting Reads counts | ||||||
|---|---|---|---|---|---|---|
| A (TSO 500) | B (Lung Cancer Panel v3.0) | C (OCA v3) | D (OncoPanel v.4.3) | E (TSO 500) | F (OCA v3) | |
| TPM3-NTRK1 | 234 | 44 | 39,211 | NA | 278 | 21,468 |
| LMNA-NTRK1 | 324 | 29 | - | NA | 426 | - |
| IRF2BP2-NTRK1 | 188 | 35 | 112 | NA | 341 | - |
| TFG-NTRK1 | 184 | 14 | 46,023 | NA | 174 | 114,933 |
| SQSTM1-NTRK1 | 266 | 31 | 7,200 | NA | 418 | 33a) |
| AFAP1-NTRK2 | 133 | 53 | 17,371 | NA | 205 | 16a) |
| QKI-NTRK2 | 191 | 5 | 38,997 | NA | 229 | 1,611,524 |
| TRIM24-NTRK2 | 163 | - | 5,791 | NA | 172 | 28a) |
| NACC2-NTRK2 | 168 | - | 16,377 | NA | 199 | 743,802 |
| PAN3-NTRK2 | 152 | 32 | NC | NA | 320 | NC |
| ETV6-NTRK3 (E5N14) | 147 | 70 | 28,094 | NA | 268 | 489 |
| ETV6-NTRK3 (E5N15) | 97 | 68 | 16,823 | NA | 224 | 1,955 |
| ETV6-NTRK3 (E4N15) | 153 | 18 | 1,024 | NA | 194 | 3a) |
| ETV6-NTRK3 (E4N14) | 192 | 16 | 2,391 | NA | 212 | 4a) |
| BTBD1-NTRK3 | 100 | 58 | 40,086 | NA | 167 | 29,051 |
NTRK, neurotrophic receptor tyrosine kinase; OCA, Oncomine Comprehensive Assay; TSO, TruSight Oncology.
a)
Detected but filtered out because < 40 reads.