Table 5.

Hazard ratios and 95% confidence intervals representing the associations of habitual recreational physical activity with all-cause and cancer mortality by tumor stage

Tumor Stage	Habitual Recreational Physical (in)activity Status	All-cause Mortality				Cancer-specific Mortality
		HR	95% CI		p-value	HR	95% CI		p-value
			CI lower	CI upper			CI lower	CI upper
Stage I	Habitually inactive	Ref				Ref
	Inactive pre; active post (increased RPA)	0.77	0.42	1.40	0.389	0.64	0.28	1.44	0.280
	Active pre; inactive post (decreased RPA)	0.97	0.67	1.40	0.872	0.99	0.61	1.60	0.969
	Habitually active	0.63	0.45	0.87	0.005	0.56	0.36	0.87	0.011
Stage II	Habitually inactive	Ref				Ref
	Inactive pre; active post (increased RPA)	0.71	0.40	1.28	0.253	0.42	0.16	1.06	0.067
	Active pre; inactive post (decreased RPA)	0.67	0.47	0.95	0.023	0.85	0.55	1.31	0.451
	Habitually active	0.47	0.34	0.64	<0.001	0.56	0.37	0.83	0.004
Stage III	Habitually inactive	Ref				Ref
	Inactive pre; active post (increased RPA)	0.76	0.50	1.15	0.193	0.73	0.45	1.17	0.186
	Active pre; inactive post (decreased RPA)	0.85	0.65	1.11	0.234	0.96	0.72	1.28	0.768
	Habitually active	0.53	0.42	0.68	<0.001	0.56	0.43	0.73	<0.001
Stage IV	Habitually inactive	Ref				Ref
	Inactive pre; active post (increased RPA)	0.78	0.55	1.09	0.145	0.77	0.54	1.10	0.152
	Active pre; inactive post (decreased RPA)	0.95	0.77	1.17	0.602	0.96	0.77	1.19	0.690
	Habitually active	0.83	0.68	1.00	0.051	0.81	0.67	0.99	0.040
Unstaged (unknown or N/A)	Habitually inactive	Ref				Ref
	Inactive pre; active post (increased RPA)	0.74	0.42	1.31	0.302	1.02	0.56	1.88	0.940
	Active pre; inactive post (decreased RPA)	0.76	0.54	1.07	0.120	0.80	0.53	1.19	0.270
	Habitually active	0.75	0.56	1.02	0.066	0.82	0.58	1.16	0.256
Habitual RPA × tumor stage		p-for-interaction = 0.051				p-for-interaction = 0.227

^aAll multivariable models in primary analyses are adjusted for age, sex, tumor stage, smoking status; tumor stage × habitual RPA