Table 3.
Neurobehavioral test | Saline P1 | LPS P1 | Saline P11 | LPS P11 |
---|---|---|---|---|
n=18 | n=128 | 16 | n=33 | |
Tone, forelimbs | 2±0, (2) | 2.2±0.0, (2)** | 2±0, (2) | 2±0, (2)§§ |
Tone, hind limbs | 1±0, (1) | 1.2±0.0, (1)** | 1±0, (1) | 1±0, (1)§ |
Righting Reflex | 10±0, (10) | 9.2±0.2, (10)** | 10±0, (10) | 10±0, (10)§§ |
Locomotion Time Forelimbs | 4±0, (4) | 3.6±0.1, (4)** | 4±0, (4) | 3.7±0.1, (4) |
Locomotion Time Hind Limbs | 4±0, (4) | 3.5±0.1, (4)** | 4±0, (4) | 3.5±0.1, (4)## |
Trunk | 4±0, (4) | 3.6±0.1, (4)** | 4±0, (4) | 3.9±0.1, (4) |
Neck | 4±0, (4) | 3.6±0.1, (4)** | 4±0, (4) | 3.9±0.0, (4)§§ |
Range of Motion Forelimb | 4±0, (4) | 3.8±0.1, (4)** | 4±0, (4) | 3.9±0.0, (4) |
Range of Motion Hind Limb | 4±0, (4) | 3.7±0.1, (4)** | 4±0, (4) | 3.9±0.1, (4) |
Smell response to peppermint | 1.0±0.1, (1.0) | 1.4±0.1, (1.0) | 1.5±0.3, (1.0) | 1.4±0.2, (1.0) |
Smell response to alcohol | 0.9±0.2, (0.5) | 1.2±0.1, (1.0)* | 1.3±0.3, (1.0) | 0.9±0.1, (1.0) |
Smell response to amyl acetate | 1.4±0.2, (1.0) | 1.8±0.2, (1.5) | 2.6±0.2, (2.3) | 1.2±0.2, (1.0)## |
Tactile response to face | 1.8±0.2, (2.0) | 1.9±0.1, (1.5) | 3.3±0.1, (3.3) | 3.1±0.1, (3.5)§§ |
P1 LPS compared to P1 Saline if significant is depicted by
P11 LPS compared to P11 Saline is depicted by
P1 LPS compared to P11 LPS is depicted by
Mean+SEM, (Median).
p<0.0038 (alpha error taking into account Bonferroni correction for multiple comparisons),
p<0.00038, two sample t-test.