Table 2.
Changes of blood pressure and biochemical parameters of PA patients before and after esaxerenone treatment. Data are mean ± SD.
| Before | After | P-value | |
|---|---|---|---|
| Systolic blood pressure (mmHg) | 134.2 ± 12.1 | 128.6 ± 12.5 | 0.0039∗ |
| Diastolic blood pressure (mmHg) | 81.1 ± 9.6 | 78.3 ± 8.5 | 0.0601 |
| Plasma aldosterone concentration (pg/mL) | 288.3 ± 211 | 321.5 ± 191 | 0.0125∗ |
| Plasma renin activity (ng/mL·h) | 0.86 ± 0.90 | 1.03 ± 1.51 | 0.2419 |
| Potassium level (mmol/l) | 3.94 ± 0.33 | 4.05 ± 0.41 | 0.1201 |
| Creatinine (mg/dl) | 0.82 ± 0.28 | 0.89 ± 0.28 | <0.001∗ |
| eGFR1 (mL/min/1.73 m2) | 72.1 ± 20.7 | 66.5 ± 18.9 | <0.001∗ |
| UACR2 (mg/g creatinine) | 130.4 ± 440 | 78.9 ± 300 | 0.131 |
| BNP3 (pg/mL) | 26.3 ± 38.8 | 25.3 ± 43.9 | 0.75 |
1eGFR: estimated glomerular filtration rate; 2UACR: urine albumin-to-creatinine ratio; 3BNP: B-type natriuretic peptide; ∗significant P value (P < 0.05).