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. 2023 Jan 17;2023:6811625. doi: 10.1155/2023/6811625

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Copyright © 2023 Kai Lei et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Comparison of the gene mutation landscape and the expression of immunomodulatory targets between two clusters. Mutational landscapes of cluster 1 (a) and cluster 2 (b). (c) Comparison of the tumor mutation burden (TMB) level between the two clusters. The expression levels of key genes in activating immune (d) and IFN γ signature (e) pathways were compared between the two clusters. The expression levels of PD1-related (PD1, PDL1, and PDL2) (f) and CTLA4-related (CTLA4, CD80, and CD86) (g) and other (LAG3, TIM3, and TIGIT) (h) immune checkpoints were compared between the two clusters. ns: no significance. ^∗p < 0.05 and ^∗∗∗p < 0.001.