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. 2023 Jan 9;29(1):104–114. doi: 10.1038/s41591-022-02128-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — (a) Ratio of CD4⁺ to CD8⁺ cell subsets within the transduced cells infused, derived from immunophenotyping: Ratios greater than 1 denote a CD4 bias in the transduced cells. Horizontal lines denote median values. Samples are grouped and color coded by BOR resulting from the infusion (blue PR, gray SD, red PD, black NE). Ratio of PR range 0.19–16.16 (median 1.30, n = 9) vs. SD range 0.03–11.58 (median 1.26, n = 16) vs. PD range 0.76–12.52 (median 3.94, n = 6). (b) Memory subset distribution by immunophenotyping within the transduced cells infused: The proportion of live single transduced afami-cel within the respective memory subsets is indicated by box plots for CD8⁺ afami-cel on the left and for CD4⁺ on the right. Samples are grouped and color coded by BOR resulting from the infusion (blue PR, gray SD, red PD, black NE). CM = central memory, CD45RA^-CCR7⁺; EM = effector memory, CD45RA^-CCR7^-; EMRA = effector memory RA⁺, CD45RA⁺ CCR7^-; SCM = stem cell memory, CD45RA⁺ CCR7⁺. Two-sided paired Wilcoxon test P values are shown linking compared cell types. Box plots depict median as horizontal lines within boxes, with box bounds as the first and third quartiles. Dots represent individual data points. Lower whisker is the minimum value of the data within 1.5 times the interquartile range below the 25^th percentile. Upper whisker is the maximum value of the data within 1.5 times the interquartile range above the 75^th percentile. BOR, best overall response; DEX, dextramer; NE, not evaluable; PD, progressive disease; PR, partial response; SD, stable disease.