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. 2023 Jan 9;29(1):75–85. doi: 10.1038/s41591-022-02097-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, b) Unsupervised hierarchical clustering of CSF differentially expressed metabolites in positive (POS) and negative (NEG) mass spectrometry modalities between baseline and 3-month follow-up and the related heatmap in the low-dose (n. 6) (a) and high-dose (n. 6) (b) groups of patients. The pathway analysis performed on these metabolites revealed the involvement of pathways related to phenylalanine, tyrosine, and tryptophan biosynthesis and metabolism in the low-dose (c) and high-dose (d) groups of patients. Comparisons were performed using a two-sided paired Student T-test. Significance levels were adjusted with the Benjamini-Hochberg multitest correction.