Extended Data Fig. 8. Considerable overlap between GLIPH2-identified TCR similarity clusters and TCRdist3-identified metaclone clusters found to be differentially abundant between controllers and progressors.

(a) Pie chart showing the proportions of differentially abundant GLIPH2 similarity clusters that shared at least one CDR3β sequence with a differentially abundant TCRdist3 metaclone cluster. (b) Histogram showing the distribution of overlap in TCR clusters with significant association with outcome obtained from GLIPH2 or tcrdist3 when the controller and progressor status was randomized 1000 times. The vertical line on the right indicates the proportion of overlap observed when the correct classification was used (34.8%), which falls at the 94.8th percentile of the 1000 permutations.