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. 2023 Jan 16;29(1):190–202. doi: 10.1038/s41591-022-02114-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — Each column represents the expression profile of the APA or NFA. Both genes and individual APAs are hierarchically clustered. Three nodes of interest are shown: a. node containing CYP11B2; b. node showing most upregulated genes in CACNA1D-mutant APAs. c. node showing most upregulated genes in KCNJ5-mutant APAs. The CYP11B2 nodes includes several genes previously noted to be upregulated in APAs, for example VSNL1, CALN1. Genes which are significantly upregulated in APMs are also seen in this node: TMEM266 (TMEM266 (C15ORF27), PPP1R16B, SEMA3D, KIAA1549L (C11ORF41), CFAP221 (PCDP1). Red represents upregulation and blue represents downregulation of genes. APA, aldosterone producing adenoma; AAG, adjacent adrenal gland; IHC, immunohistochemistry; NFA, non-functioning adenoma; APM, aldosterone producing micronodule (previously known and aldosterone producing cell clusters, APCCs).