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. 2023 Jan 16;29(1):190–202. doi: 10.1038/s41591-022-02114-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Change in aldosterone, renin and ARR observed at baseline (time 0) and after surgery and medical therapy, divided into cohorts where a. Renin activity (SBH) and b. Renin mass was measured (GSTT and CUH). A similar trend is observed in both cohorts. Data are least squares means from mixed effects models, adjusted for baseline covariates. Error bars show 95% CI. 0 months indicate baseline visit. For aldosterone levels with renin mass: Surgical group: n = 64 at 0 months, n = 51 at 6 months, n = 27 at 12 months, n = 15 at 24 months. Medical group: n = 50 at 0 months, n = 32 at 9 months, n = 9 at 24 months. For renin as renin mass: Surgical group: n = 64 at 0 months, n = 53 at 6 months, n = 28 at 12 months, n = 16 at 24 months. Medical group: n = 51 at 0 months, n = 32 at 9 months, n = 10 at 24 months. For ARR calculated using renin mass: Surgical group: n = 64 at 0 months, n = 51 at 6 months, n = 27 at 12 months, n = 15 at 24 months. Medical group: n = 50 at 0 months, n = 32 at 9 months, n = 9 at 24 months. For aldosterone levels with renin activity: Surgical group: n = 41 at 0 months, n = 40 at 6 months, n = 35 at 12 months, n = 18 at 24 months. Medical group: n = 40 at 0 months, n = 40 at 9 months, n = 16 at 24 months. For renin as renin activity: Surgical group: n = 41 at 0 months, n = 41 at 6 months, n = 36 at 12 months, n = 18 at 24 months. Medical group: n = 42 at 0 months, n = 40 at 9 months, n = 16 at 24 months. For ARR calculated using renin activity: Surgical group: n = 41 at 0 months, n = 40 at 6 months, n = 35 at 12 months, n = 18 at 24 months. Medical group: n = 40 at 0 months, n = 40 at 9 months, n = 16 at 24 months. SBH, St Bartholomew’s Hospital; GSTT, Guy’s and St Thomas’ Hospital; CUH, Cambridge University Hospital.