Extended Data Table 2.

Clinical and biochemical parameters

Clinical and biochemical parameters used in the calculation of primary and secondary outcomes. Data for patients managed with surgery or medical therapy is also shown. Unless otherwise stated numbers show mean; round brackets indicate standard deviation; square brackets indicate n (number of patients). For categorical data the Fisher Exact test was used. For continuous data the Mann-Whitney-Wilcoxon test was used. Reference ranges: Sodium 133-146 mmol/L, Potassium 3.5-5.3 mmol/L, Bicarbonate 22-29 mmol/L, Creatinine 45-105 mmol/L, Aldosterone 150-550 pmol/L, Renin mass 5.4-30 mU/L, Renin activity 0.5-3.0 nmol/L/hr, ARR (mass) <91 pmol/mU, ARR (activity) <1000 (pmol/L)/(nmol/L/hr), BNP < 400 ng/L, Troponin T < 14 ng/L (St Bartholomew’s and Guy’s and St Thomas’ Hospital), Troponin I < 58.1 ng/L (Cambridge University Hospital). SBP, systolic BP; DBP, diastolic BP; ARR, aldosterone renin ratio; BNP, N-terminal pro-B-type natriuretic peptide; NDC, number of different classes of antihypertensive medications; DDD, defined daily dose; SD, standard deviation; IQR, interquartile range.