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. 2023 Jan 24;10:50. doi: 10.1038/s41597-022-01886-2

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© The Author(s) 2023, corrected publication 2023

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Fig. 3 — Representative schema for data-driven classification. Blue nodes (i1–3) are OWL individuals representing clusters of single-cell transcriptomes, while tan nodes (c1, c2) are OWL classes representing cell types. Hierarchical clustering is represented using the transitive subcluster_of relation (objectProperty) to link individuals. Each class is defined by reference to a cluster individual (i), via the relation (objectProperty) as equivalent to (any) cell that has_examplar (value) i. Reasoning via a chain of these two properties (bottom and right sides of the diagram above) is sufficient to infer that c3 has_examplar value i1 and so, combined with the assertion that it is a (type of) cell, fulfils the conditions required to be a subclass of i1.