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. 2023 Jan 24;10:50. doi: 10.1038/s41597-022-01886-2

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Example of an automatically generated class displayed in the Protege ontology browser. In this example, we show L5 Extratelencephalic (ET), which is a grouping class. The label, definition, and set of synonyms are auto-generated from OWL templates using a Dead Simple OWL Design Patterns (DOSDP) system. Automatic axiomatisation includes brain region, species, NS-Forest markers, projection pattern, morphology, named markers, and has_exemplar_data link to taxonomy node (cluster), using a reification pattern. This results in the reasoner classifying this class under L5 extratelencephalic projecting glutamatergic cortical neuron (based on automated axiomatisation of brain region and projection pattern), and primary motor cortex pyramidal cell (based on automated axiomatisation of morphology and brain region). has_characterzing_marker_set schema for NS-Forest is also shown.