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. 2023 Jan 25;14:399. doi: 10.1038/s41467-023-36163-2

Fig. 6. HIV-1 infection associated polyamine increase is dependent on ODC-1 activity.

Fig. 6

HTOC CD4+ T cells were TCR activated and infected with HIV. ARI and ODC-1 inhibitor I were added as indicated, 36 h post-infection. Quantification of putrescine (A), spermidine (B), spermine (C), and cadaverine (D) relative to the uninfected controls are shown (top). Thermospermine was not detected. Means with standard deviation error bars from three independent experiments are shown. n = 3 independent experiments. Unpaired t test one-tailed with Welch’s correction; *P values 0.0126–0.0243, **P values 0.0038–0.0085 in A–D. Circles within box plots represent each replicate. Absolute levels (normalized to the input cell numbers) of the respective polyamines from one of the three independent experiments (bottom).