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. 2023 Jan 24;14:396. doi: 10.1038/s41467-023-35907-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Schematic illustration of the diabetic wound model in SD rats. b Representative images of the wound healing behavior and dynamic wound healing process on day 0, 3, 7, 10, and 14. c The wound healing ratio on day 0, 3, 7, 10, and 14 (n = 7 rats created over 2 independent wounds in each group, two-tailed t test was used, *P < 0.05, **P < 0.01, ***P < 0.001). d H&E-stained images of the wound tissue on day 7 and 14. e The granulation tissue thickness in wound tissue on day 7 and 14 (n = 3 biologically independent samples in each group). f Masson staining of the wound tissue on day 7 and 14. g The collagen deposition ratio of wound tissue on day 7 and 14 (n = 3 biologically independent samples in each group). h Representative images of CD31 and α-SMA immunostaining in wound tissue on day 7 and 14. I, j Quantification of the number (i) and diameter (j) of vessels in the wound tissue (n = 9 biologically independent samples in each group). For (c, e, g, i, and j), two-tailed t test was used. Data are presented as mean values ± SEM. Scale bars, 1 mm (images in d, f), 200 μm (inset in d, f), 100 μm (images in h). Source data are provided as a Source data file.