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. 2023 Jan 24;14:396. doi: 10.1038/s41467-023-35907-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a, b Volcano plots showing the upregulated and downregulated genes in d-SMG group on day 3 (a) and 14 (b). c, d Heat map of inflammation genes on day 3 (c) and wound healing genes on day 7 and 14 (d). e Gene ontology (GO) enrichment analysis of the downregulated genes on day 3. f GO enrichment analysis of the upregulated genes on day 14. g The relative mRNA level in the diabetic wound tissue evaluated using real-time qPCR (n = 3 biologically independent samples in each group). For (a, b), Wald test was used; For (e,f), Hypergeometric tests and Benjamini–Hochberg FDR control procedures were used; For (g), two-tailed t test was used. Data are presented as mean values ± SEM. Source data are provided as a Source data file.