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. 2022 Oct 6;25(2):352–363. doi: 10.1007/s12094-022-02957-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Introduction to PROTAC. A Illustration of PROTAC structure. A PROTAC comprises a specific binding unit to bind targeted protein, an E3 ligase recruiting unit, and one linker between them. B A graphical representation of the yearly growth in PROTAC publications from 2003 to 2022. Publications on all PROTACs and PROTACs in PCa were searched from PubMed (https://www.ncbi.nlm.nih.gov/pubmed). The literature was presented chronologically from 2003. Columns indicated the number of publications of all PROTACs and PROTACs in PCa