Table 2.
Demographic, clinical features, and laboratory data comparison of the moderately active and highly active patient groups with CNS-pSS
| Characteristic | Moderately active group (N = 9) | Highly active group (N = 33) | p value |
|---|---|---|---|
| Sex, female, n (%) | 9 (100) | 28 (84.8) | 1.000 |
| age (mean ± SD), years | 48.78 ± 16.52 | 49.70 ± 16.97 | 0.886 |
| Disease duration, months | 63.11 (18.4, 121.2) | 34.48 (21.8, 47.6) | 0.307 |
| Xerostomia, n (%) | 8 (88.9) | 28 (84.8) | 1.000 |
| Xerophthalmia, n (%) | 5 (55.6) | 15 (54.5) | 0.714 |
| Arthralgia, n (%) | 2 (22.2) | 17 (51.5) | 0.149 |
| Skin rash, n (%) | 0 (0) | 11 (33.3) | 0.083 |
| Fever, n (%) | 2 (22.2) | 3 (9.1) | 0.288 |
| Lung involvement, n (%) | 0 (0.0) | 12 (36.4) | 0.041 |
| Kidney involvement, n (%) | 0 (0.0) | 4 (12.1) | 1.000 |
| ANA (1:1000) positive, n (%) | 1 (11.1) | 18 (54.5) | 0.027 |
| Anti‐SSA positive, n (%) | 8 (88.9) | 29 (87.9) | 1.000 |
| Anti‐SSB positive, n (%) | 1 (11.1) | 12 (36.4) | 0.232 |
| RF positive, n (%) | 3 (33.3) | 16 (48.5) | 0.477 |
| ESR > 20 mm/h, n (%) | 5 (55.6) | 18 (54.5) | 1.000 |
| CRP > 8 mg/L, n (%) | 2 (22.2) | 5 (15.2) | 0.631 |
| C3 (mean ± SD), g/L | 0.81 ± 0.19 | 0.91 ± 0.32 | 0.387 |
| C4 (mean ± SD), g/L | 0.17 ± 0.06 | 0.18 ± 0.07 | 0.575 |
| IgG (mean ± SD), mg/mL | 14.5 ± 5.23 | 16.1 ± 4.26 | 0.135 |
| IgA (mean ± SD) mg/mL | 1.98 ± 1.78 | 3.19 ± 1.75 | 0.684 |
| IgM (mean ± SD), mg/mL | 0.91 ± 0.53 | 1.50 ± 1.01 | 0.460 |
| WBC (mean ± SD), × 109/L | 6.41 ± 2.55 | 6.23 ± 5.19 | 0.385 |
| Hb (mean ± SD), g/L | 115.33 ± 9.89 | 112.58 ± 19.49 | 0.975 |
| PLT < 100 × 109/L, n (%) | 0 (0.0) | 12 (36.4) | 0.041 |
| ALT (mean ± SD), u/L | 23.47 ± 15.34 | 39.52 ± 33.28 | 0.668 |
| AST (mean ± SD), u/L | 18.11 ± 8.65 | 40.90 ± 40.76 | 0.624 |
| ALB albumin | 35.41 ± 3.75 | 36.76 ± 4.18 | 0.385 |
ANA, antinuclear antibodies; C3, complement component 3; C4, complement component 4; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; RF, rheumatoid factor; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; WBC, white blood cell; Hb, hemoglobin; PLT, platelet; ALT, alanine transaminase; AST, aspartate aminotransferase