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. 2023 Jan 25;9:28. doi: 10.1038/s41420-023-01309-0

Fig. 3. Gut microbiota is required for endometriotic lesion growth in mice.

Fig. 3

A, E Schematic of experimental timeline and procedures for A suture model and E injection model for the fecal microbiota transfer (FMT) experiments. Microbiota-depleted mice underwent endometriosis induction and received an oral gavage of PBS (MD + PBS), feces from mice without endometriosis (MD + NE) or feces from mice with endometriosis (MD + E). B, F Ectopic endometriotic lesion representative images from B suture model and F injection model. C, G Ectopic lesion volumes from C suture model and G injection model. D, H Ectopic lesion masses from D suture model and H injection model from the indicated groups 21 days after the induction of endometriosis. I Number of lesions per mouse in injection model from the indicated groups 21 days post-induction of endometriosis. All the indicated data is 21 days after induction of endometriosis. Data are presented as mean ± SE (n = 5), *P < 0.05, **P < 0.01, ***P < 0.001, and ns, nonsignificant.