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. 2023 Jan 25;9:28. doi: 10.1038/s41420-023-01309-0

Fig. 7. Fecal metabolites differ between mice with and without endometriosis.

Fig. 7

A The heat map depicting the metabolites that were differentially present between mice with and without endometriosis with cutoff of FDR < 0.25. B Quinic acid is present at higher level in feces of mice with endometriosis. Stool samples from mice with and without endometriosis were subjected to LC-MS (in the Baylor College of Medicine Metabolomics Core) to detect ~150 water-soluble metabolites. Each row is a metabolite, and each column is a stool sample from an individual mouse; (n = 5 mice per group). Data are presented as mean ± SE. C MTT cell viability assays of iHEECs/Luc treated with 20 mM and 40 mM Quinic acid for indicated time points. Results are shown as mean ± SE (n = 3) and experiment repeated three times. Ectopic endometriotic lesion D representative images, E number of lesions per mouse, F volumes and G masses from the vehicle and QA treated groups,14 days after induction of endometriosis. Data are presented as mean ± SE (n = 5), *P < 0.05, **P < 0.01, ***P < 0.001 and ns, non-significant.