Figure 6.

Patients with immune-related pneumonitis have distinctive distributions of T cell populations

(A) Representative chest CT scans of patients with chronic hypersensitive pneumonitis (CHP) and organized pneumonia (OP) at baseline and on treatment.

(B) Representative KNetL plot indicating key clusters to be used to distinguish the pneumonitis groups.

(C) Cells of patients with CHP are enriched in clusters C10, C3, and C4.

(D) Cells of patients with OP are depleted in clusters of C22 and C25.

(E) Quantification of the mean percentage differences in CD3 T cell subsets among the different pneumonitis groups.

(F) Heatmap showing the RNA expression of differentially expressed genes between CHP and OP groups within the clusters C10, C22, and C25.

Statistical significance for unpaired comparisons was performed by Student’s t test applying Mann-Whitney test. Data are presented as mean ± SEM. p value, exact, two-tailed, the center lines denote the mean of SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.