Table 2.

Relationship between serum IL-6, IL-8, and IL-10 levels and clinicopathological characteristics in female dogs with malignant CMGTs.

Characteristics	N	IL-6 (ng/L)	P-value	IL-8 (ng/L)	P-value	IL-10 (ng/L)	P-value
Ages
≥ 8	18	159.5 ± 46.14	0.4195	727.1 ± 161.7	0.5919	255.2 ± 49.69	0.3998
< 8	34	171.3 ± 51.4		701.4 ± 166.6		242.6 ± 52.6
Size (cm)
T1 (< 3)	8	141.1 ± 34.82	0.0938	685.2 ± 148	0.7805	240.6 ± 39.46	0.5671
T2 (3 ≤ T ≤ 5)	27	168.5 ± 48.01		717.5 ± 155.3		247.4 ± 47.69
T3 (> 5)	17	188.4 ± 58.42		735.0 ± 185.1		261.2 ± 59.87
Metastasis state
Yes	12	199.7 ± 54.76	*0.0251	756.3 ± 157.2	0.3599	275.7 ± 39.3	0.0509
No	40	162. ± 47.9		706.8 ± 163.9		243.4 ± 51.57
Histologic grade
I	16	144 ± 42.72	#0.0014	567.9 ± 101.3	#0.0001	221 ± 42.56	**0.0015
II	24	165.8 ± 46.74		746.7 ± 121.5		252.5 ± 45.57
III	12	216.6 ± 43.21		861.8 ± 141.5		287.4 ± 47.8
Molecular subtype
Luminal A	14	169.5 ± 41.53	**0.008	708.1 ± 145.9	#0.0463	246.3 ± 59.21	0.1534
Luminal B	24	165.7 ± 53.8		775.4 ± 174.6		265.5 ± 45.94
Her-2 positive	8	142.6 ± 31.03		619.3 ± 105.9		227.0 ± 45.63
Basal-like	6	231.8 ± 45.7		645.2 ± 137.9		234.7 ± 45.04

*Denotes unpaired t test; **denotes One-way ANOVA test; ^#denotes Kruskal–Wallis; P < 0.05 was considered to be statistically significant.