Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 24;14:392. doi: 10.1038/s41467-023-36045-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — a Tumor growth curve of left-side tumors including primary (P) tumors from mice with cryosurgery and left (L) tumors from mice without cryosurgery (n = 6 mice). The mice were also injected with one of the formulations including: PBS, free CPT&siR, CPT CRNPs, siR CRNPs, or CPT&siR CRNPs. b Tumor growth curve of right-side tumors including distant (D) tumors from mice with cryosurgery on P tumors and right (R) tumors from mice without cryosurgery (n = 6 mice). The mice were also injected with one of the indicated formulations. c, d Weight of left-side (L versus P, c) and right-side (R versus D, d) tumors (n = 6 mice) obtained after sacrificing the mice at the end of the study, showing effective tumor destruction by the ICIE treatment. e Representative hematoxylin and eosin (H&E) staining images of left-side (L versus P) and right-side (R versus D) tumors, showing extensive necrosis in both the primary and distant tumors from mice with the ICIE treatment. The experiments were repeated three times independently (n = 3 mice) with similar results. Statistical analyses were done using two-way ANOVA with Sidak’s post-test and correction for multiple comparisons. Data are presented as mean ± SD (c, d). Source data are provided as a Source Data file.