TABLE 1.

Wound therapy approaches (Mihai, et al., 2018).

Therapeutic approach	Advantages		Disadvantages		Indication		Example
Wound debridement	-	Disruption of the mucopolysaccharide matrix. Destabilizes the biofilm's architecture promotes bacterial detachment increases antimicrobial delivery	-	Many promote the inoculation of infection in deeper tissues	-	Chronic wounds	-	Mehanical
	-						-	Enzymatic
	-						-	Biological
	-
Topical or systemic antibiotic theraphy	-	Low cost	-	Development of antibiotic resistance	-	Acute wounds	-	Fluoroquinolones, tetracycline,rifampin, daptomycin, and vancomycin
	-	Efficient in acute infections	-	Development of antibiotic tolerance in biofilms
	-	Eradication of planktonic bacteria	-	Microbial inbalance (target both pathogenic and beneficial bacteria)
	-	Biofilm disruption	-	Multiple side effects
Topical antiseptic therapy	-	Cytotoxic toward bacteria, fungi, and others microorganisms	-	Might damage host cell and adversely affect wound healing	-	Acute wounds	-	Povidone-iodine, chlorhexidine, hedrogen, peroxide, boric acid, silver Sulfadiazine or nitrate, sodium hypochlorite, mafenide acetate, octenidine dihydrochloride, Ployhexamethylene biguanide (ployhexanide)
					-	Chronic wounds
Bacteriophage therapy	-	May be efficient against polymicrobial bio film-mediated infections	-	Biological-associated risks	-	Chronic wounds	-	Monophage preparations (staphylococcal bacteriophages, pyocianic bacteriophages)
	-	Very specific for targeted bacterial species	-	Unknown side effects			-	Multiple phage preparations
			-	High production costs
			-	Applied in low amount as a topic treatment
Antimicrobial peptides	-	Antimicrobial properties	-	Used in small amounts	-	Chromic Wounds	-	Defensins, magainins, cecropins
			-	Low stability
			-	Increased volatility
Probiotic theraphy	-	Accelerates wound healing	-	Insufficient data	-	Chromic Wounds	-	Lactobacillus plantarum
	-	Prevents wound colonization, biofilm developent
	-	Interferes with the quorum sensing of p. aeruginoa