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. 2022 Dec 15;99(2):fiac153. doi: 10.1093/femsec/fiac153

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© The Author(s) 2022. Published by Oxford University Press on behalf of FEMS.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Schematic of the aerobic methane oxidation pathway. The colored boxes, which are color coded for taxonomy, correspond to the presence (colored boxes) or absence (empty boxes) of genes coding for enzymes necessary for these steps in the nGOM MAGs. Blue arrows indicate oxidation steps. The abbreviations shown in the figure are as follows: pmoA/AMO: particulate methane monooxygenase/ammonia monooxygenase; MDH: methanol dehydrogenase; SDR: short-chain alcohol dehydrogenase; ALDH: aldehyde dehydrogenase; H4MPT: tetrahydromethanopterin pathway; FAE: formaldehyde-activating enzyme; MtdB: methylene tetrahydromethanopterin dehydrogenase; Mch: methenyl-tetrahydromethanopterin cyclohydrolase; Ftr/Fhc: formylmethanofuran-tetrahydromethanopterin formyltransferase; H4F: tetrahydrofolate pathway; folD: tetrahydrofolate dehydrogenase/cyclohydrolase; Fhs: formate–tetrahydrofolate ligase; GSH: glutathione-dependent pathway; Gfa: glutathione-dependent formaldehyde activating enzyme; GD-FALDH: glutathione-dependent formaldehyde dehydrogenase; FGH: Formyl-glutathione hydrolase; FDH: formate dehydrogenase.