TABLE 4.

Risk factors for 30-day mortality in patients with COVID-19.

	Univariate model		Multivariate model
	HR (95% CI)	P-value	Adjusted HR (95% CI)	P-value
Severity of hyponatremia
Mild	1.56 (1.44–1.70)	<0.001
Moderate	2.76 (2.47–3.09)	<0.001	1.24 (1.04–1.48)	0.02
Severe	3.02 (2.65–3.44)	<0.001	1.71 (1.40–2.09)	<0.001
Demographics
Age	1.06 (1.06–1.06)	<0.001	1.03 (1.03–1.04)	<0.001
Male sex	1.35 (1.27–1.43)	<0.001
Comorbidities
Diabetes mellitus	1.71 (1.61–1.83)	<0.001
Hypertension	2.37 (2.22–2.52)	<0.001
Ischemic heart disease	1.97 (1.83–2.12)	<0.001
Cerebrovascular accident	2.31 (2.15–2.50)	<0.001	1.19 (1.04–1.36)	0.01
COAD	2.07 (1.87–2.29)	<0.001	1.51 (1.27–1.81)	<0.001
Active malignancy	1.56 (1.45–1.68)	<0.001
Dementia	2.62 (2.45–2.81)	<0.001
Congestive heart failure	2.48 (2.29–2.68)	<0.001
Arrhythmia	2.28 (2.13–2.45)	<0.001	1.23 (1.08–1.41)	0.002
Chronic liver disease	1.50 (1.35–1.67)	<0.001
Laboratory parameters
SARS-CoV-2 PCR Ct value	0.97 (0.96–0.97)	<0.001	0.98 (0.97–0.99)	<0.001
Hemoglobin	0.79 (0.78–0.80)	<0.001	0.97 (0.94–0.99)	0.01
White cell count	1.02 (1.02–1.02)	<0.001	1.02 (1.01–1.03)	<0.001
eGFR (by CKD-EPI equation)	0.97 (0.97–0.97)	<0.001	0.99 (0.99–0.99)	<0.001
Albumin	0.88 (0.87–0.88)	<0.001	0.95 (0.94–0.96)	<0.001
C-reactive protein	1.10 (1.10–1.11)	<0.001	1.07 (1.06–1.08)	<0.001
D-dimer (for every 1,000 ng/ml rise)	1.22 (1.20–1.23)	<0.001	1.03 (1.01–1.06)	0.008

COVID-19, coronavirus disease-2019; CI, confidence interval; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; RT-PCR, reverse transcription polymerase chain reaction; Ct value, cycle threshold value; COAD, chronic obstructive airway disease; eGFR, estimated glomerular filtration rate; CKD-EPI, chronic kidney disease epidemiology collaboration.