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. 2022 Dec 30;51(1):68–83. doi: 10.1093/nar/gkac1204

Figure 6.

Figure 6.

Genome-wide effects of enhancer–promoter interactions on transcriptional burst kinetics in three cases of feedback regulation. (A) Illustration of the E–P interaction with a positive feedback loop. (B) Dependence of noise (rCV2) on E–P interaction intensity for different feedback forms, where the dashed line represents the valley in case of positive feedback and the line segment on the right-hand side of the picture represents the maximum minus the minimum, that is, the amplitude of affecting the variability. Color: positive (red line), negative (green line), and non-feedbacks (blue line). (C) Dependences of normalized burst frequencies and sizes on E–P interaction intensity in the case of positive feedback.

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