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. 2022 Oct 7;36(12):4477–4490. doi: 10.1002/ptr.7651

FIGURE 8.

FIGURE 8

Schematic representation of binding of compound 43 to the SARS‐CoV PLpro active site (PDB code: 3MJ5). As highlighted in red, the most important interacting sequences in the active site of the PLpro are Leu163, Gly164, Asp165, Pro248, Pro249, Tyr265, Tyr269, and Tyr274. In total, this enzyme has eight cysteine residues Cys112, Cys149, Cys190, Cys193, Cys225, Cys227, Cys261, and Cys271, two of which (Cys112 and Cys271) are located in the active site (graphic images were prepared and analyzed by Discovery Studio Visualizer v4.5).