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. 2022 Oct 23;110(1):99–108. doi: 10.1111/ejh.13878

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© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Pseudo‐typed virus neutralization assay and the anti‐spike antibody levels. A scatter plot of anti‐spike protein antibody titers vs. anti‐SARS CoV‐2 neutralizing antibody titers (A) reveal strong correlation between the results of two assays (Peasron's product–moment R = .67, F‐test p < .001). Boxplots shows significantly higher neutralizing antibody titers prior‐fourth vaccine (B) among untreated patients (n = 34) compared with treated patients (n = 33, Wilcoxon p = .004), (C) compared with BTKi‐treated (n = 22, p = .039) and BCL2i ± anti‐CD20‐treated patients (n = 10, p = .012), and compared with (D) patients treated with anti‐CD20 therapy (n = 34) and untreated (n = 33, p < .001)