Fig. 3.

Casirivimab (REGN 10933, heavy chain: green, light chain: orange) and imdevimab (REGN 10987, heavy chain: pink, light chain: teal) bind mutually exclusive epitopes on a portion of the RBD of the SARS‐CoV‐2 S protein (blue) (PDB ID: 6XDG, visualized with ucsf chimerax, version 1.4) [31, 32]. Casirivimab binds the top of the RBD of the virus and overlaps greatly with the binding site for ACE2. The epitope for imdevimab is located away from the epitope for casirivimab and has little overlap with the ACE2 binding site. The non‐overlapping binding sites allow for increased efficiency when binding to the virus due to the multiple binding locations. Hydrogen bonds between each of the antibodies and the RBD are represented by dotted cyan lines.