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. 2022 Nov 5:10.1111/febs.16662. Online ahead of print. doi: 10.1111/febs.16662

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© 2022 Federation of European Biochemical Societies.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Fig. 11 — (A) Structures of remdesivir monophosphate and (B) AMP. Remdesivir functions as an adenosine analog, such that RMP can replace AMP in the product RNA, thereby inhibiting the RdRp viral replication mechanism. (C) RdRp complex (NSP12: green, NSP7: pink, NSP8: teal) bound to template (yellow) and primer (blue) RNA strands and remdesivir triphosphate (purple backbone) (PDB ID: 7BV2, visualized with ucsf chimerax, version 1.4) [124, 126]. Hydrogen bonds between remdesivir triphosphate and RdRp or the RNA strands are represented by dotted cyan lines, and heteroatom colors correspond to those in the 2D visualization.