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. 2022 Nov 5:10.1111/febs.16662. Online ahead of print. doi: 10.1111/febs.16662

Fig. 12.

Fig. 12

Chemical structures of (A) ribavirin monophosphate and (B) GMP. Due to its function as a guanosine analog, ribavirin monophosphate is a broad‐spectrum antiviral because it is able to compete with IMP for binding to IMP dehydrogenase, which in turn inhibits RdRp enzyme activity as a result of the creation of nucleotide imbalance [137, 138].