FIGURE 2.

Entry mechanism of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) through host angiotensin‐converting enzyme 2 (ACE2). SARS‐CoV‐2 binds to the surface of host cells via several receptors (ACE2, neuropilin‐1, AXL, and antibody‐Fcγ receptor complexes). The spike (S) protein goes through conformational transition from prefusion to postfusion by using proteases (furin, TMPRSS2, and cathepsins). SARS‐CoV‐2 attaches with the cell receptor ACE2, which comprises integral membrane protein, and moves to the surface of cells after transcription with its N‐terminal signal peptide and binds by C‐terminal transmembrane domain. When receptor‐binding domain starts binding with the tips of one lobe of ACE2 the viral entry initiates