TABLE 4.

Mouse competition assay with CFT073 and tonB derivatives

CFT073 vs.:	No. of mice	Competitive indexa
		Bladder	Kidney
CFT073-TB	7b	0.02 ± 0.017c	0
CFT073-TB(pYUK1)	3	0.64 ± 0.43d	1.11 ± 0.09d

^aCompetitive index is the ratio of output mutant to wild-type bacteria (recovered from the bladder or kidneys) divided by the ratio of input mutant to wild-type bacteria (inoculated into the mouse). A competitive index of <1 indicates that the strain was recovered in lower numbers than the wild type. Zero indicates that no mutant bacteria were recovered from that site. P values were calculated with Student's t test. 

^bBacteria were not recovered from the kidneys of one of the mice. 

^cP < .001. 

^dP > .1.