TABLE 5.
Recovery of iron transport mutants of CFT073 from the kidneys of infected mice
| Strain | Phenotype | Infectivity ratea | No. of CFU/g of kidneyb |
|---|---|---|---|
| Trial 1 | |||
| CFT073 | Wild type | 9/9 | 5.6 × 103 (1.1 × 102–6.7 × 104) |
| CFT073-IUC | Iuc− | 8/10 | 3.5 × 104 (2.1 × 102–1.8 × 105) |
| Trial 2 | |||
| CFT073 | Wild type | 5/7 | 1.2 × 104 (1.1 × 103–5.6 × 104) |
| CFT073-LH | ChuA− | 6/9 | 2.8 × 104 (1.4 × 102–7.0 × 104) |
| Trial 3 | |||
| CFT073 | Wild type | 13/14 | 3.8 × 104c (7.0 × 102–1.4 × 105) |
| CFT073-ENT | Ent− | 14/14 | 4.1 × 103 (2.1 × 102–9.2 × 104) |
| CFT073-IUC/ENT | Iuc− Ent− | 13/17 | 1.1 × 103c (2.8 × 102–4.7 × 104) |
a
Number of animals with positive kidney cultures/number of animals inoculated.
b
Median (range) of the number of CFU/g for all animals with positive cultures.
c
P = 0.02 (Mann-Whitney); for all other comparisons, P > 0.05.