TABLE 6.
Mouse competition assay with CFT073 and its isogenic iron utilization strains
CFT073 vs.: | No. of mice | Competitive indexa
|
|
---|---|---|---|
Bladders | Kidneys | ||
CFT073-ENT/IUC | 6b | 0.90 ± 0.38c | 1.11 ± 0.52c |
CFT073-IUT | 7d | 0.008 ± 0.06e | 0 |
CFT073-LH | 7d | 0.026 ± 0.003e | 0.058 ± 0.006c |
Competitive index is the ratio of output mutant to wild-type bacteria (recovered from the bladder or kidney) divided by the ratio of input mutant to wild-type bacteria (inoculated into the mouse). A competitive index of <1 indicates that the strain was recovered in lower numbers relative to the wild type.
Bacteria were not recovered from the kidneys of two of the mice.
P ≥ 0.1.
Bacteria were not recovered from the kidneys of one of the mice.
P < .001.