Table 2.

Median procalcitonin (ProCt), calcitonin (Ct), and carcinoembryonic antigen (CEA) levels according to disease response.

Factor	NED (47/90) (52.2%)	Minimal residual disease (14/90) (15.6%)	Structural evident disease (29/90) (32.2%)	P
ProCt (ng/mL) median values (IQR)	0.04 (0.04–0.04)	0.26 (0.06–0.56)	1.98 (0.49– 11.78)	<0.01
Ct (ng/L) median values (IQR)	1.000 (1.0–2.4)	17.45 1 (1.90–57.40)	176.00 (47.70–410.75)	<0.01
CEA (ng/mL) median values (IQR)	2.00 (0.70–3.40)	2.40 (1.50–3.40)	14.35 (4.65–51.25)	<0.01a
ProCt ≤0.04, n (%)	40/47 (85.1%)	3/14 (21.4%)	0/29 (0%)	<0.01
Ct ≤10 ng/L, n (%)	47/47 (100%)	0/14 (0%)	2/29 (10%)	<0.01
	<1 ng/L: 31/47 (66.0%)		<1 ng/L: 0/29 (0%)
	>1 ng/L and ≤10 ng/L: 16/47 (34.0%)		>1 ng/L and ≤10 ng/L: 2/2 (100%)
CEA ≤ 4.7 ng/mL, n (%)	37/41 (90.2%)b	12/14 (85.7%)	6/28 (21.4%)c	<0.01a

^aBetween structural evident disease vs minimal residual disease and vs NED, there was no significant difference between NED and minimal residual disease; ^b Six missing data; ^c One missing data.

IQR, interquartile range; NED, not evident disease.