Table 3.

Biomarker response rates over time.

Biomarker	No. (%)
	Month 3	Month 6	Month 9	Month 12
Serum chromogranin A
No. of patients	43	38	28	28
Complete + partial responses	13 (30)	21 (55)	17 (61)	19 (68)
Complete response	3 (7)	8 (21)	9 (32)	8 (29)
Partial response	10 (23)	13 (34)	8 (29)	11 (39)
Stable disease	28 (65)	16 (42)	10 (36)	5 (18)
Progressive disease	2 (5)	1 (3)	1 (4)	4 (14)
Plasma free normetanephrine
No. of patients	43	39	29	25
Complete + partial responses	7 (16)	12 (31)	11 (38)	11 (44)
Complete response	1 (2)	2 (5)	2 (7)	0 (0)
Partial response	6 (14)	10 (26)	9 (31)	11 (44)
Stable disease	35 (81)	25 (64)	17 (59)	13 (52)
Progressive disease	1 (2.3)	2 (5)	1 (3)	1 (4)
Urinary normetanephrine
No. of patients	41	38	29	25
Complete + partial responses	7 (17)	8 (21)	6 (21)	9 (36)
Complete response	1 (2)	1 (3)	1 (3)	1 (4)
Partial response	6 (15)	7 (18)	5 (17)	8 (32)
Stable disease	32 (78)	26 (68)	20 (69)	13 (52)
Progressive disease	2 (5)	4 (11)	3 (10)	3 (12)
Plasma norepinephrine
No. of patients	42	38	30	29
Complete + partial responses	5 (12)	10 (26)	10 (33)	9 (31)
Complete response	0 (0)	0 (0)	0 (0)	1 (3)
Partial response	5 (12)	10 (26)	10 (33)	8 (28)
Stable disease	37 (88)	27 (71)	20 (67)	19 (66)
Progressive disease	0 (0)	1 (3)	0 (0)	1 (3)
Urinary norepinephrine
No. of patients	33	32	24	19
Complete + partial responses	7 (21)	10 (32)	6 (25)	8 (42)
Complete response	2 (6)	4 (13)	4 (17)	3 (16)
Partial response	5 (15)	6 (19)	2 (8)	5 (26)
Stable disease	22 (67)	19 (59)	15 (63)	9 (47)
Progressive disease	4 (12)	3 (9)	3 (13)	2 (11)