Table 5.

Correlation of overall tumor biomarker response with objective tumor response.^a

	Overall tumor biomarker response	RECIST responsea, n (%)			Correlation coefficient (P-value)
		PR	SD	PD	Fisher’s exact P-value
All baseline ≥ 1.5x ULN (n - =55)	Responder	7 (13)	6 (11)	0 (0)	0.36 (0.007) 0.012
	Non-responder	7 (13)	32 (58)	3 (5)
NE-hypersecreting (n = 52)	Responder	7 (13)	6 (12)	0 (0)	0.38 (0.005) 0.010
	Non-responder	6 (12)	30 (58)	3 (6)
NE-only-hypersecreting (n = 28)	Responder	5 (18)	5 (18)	0 (0)	0.35 (0.065) 0.091
	Non-responder	3 (11)	13 (46)	2 (7)
EPI-only-hypersecreting (n = 3)	Responder	0 (0)	0 (0)	0 (0)	N/A
	Non-responder	1 (33)	2 (67)	0 (0)

^aBest confirmed response of complete response or partial response according to Response Evaluation Criteria in Solid Tumors.

EPI, epinephrine; NE, norepinephrine; PD, progressive disease; PR, partial response; SD, stable disease; ULN, upper limit of normal.