Table 3. Logistic regression analysis: associations between the presence of plaque and the log cfDNA and clinical profiles.
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | OR | 95% CI | P-value | |
| log mt-cfDNA | 3.89 | 1.83–9.88 | <0.001 | 3.93 | 1.46–13.49 | 0.005 |
| log n-cfDNA | 1.80 | 1.10–3.09 | 0.02 | 1.10 | 0.59–2.09 | 0.76 |
| Age | 1.10 | 1.04–1.17 | <0.001 | 1.06 | 0.99–1.14 | 0.07 |
| Male | 3.89 | 1.32–13.19 | 0.01 | 1.45 | 0.35–6.26 | 0.61 |
| BMI | 1.02 | 0.92–1.13 | 0.72 | |||
| Hypertension | 1.69 | 0.55–4.95 | 0.35 | |||
| Dyslipidemia | 1.48 | 0.54–4.17 | 0.44 | |||
| Diabetes | 1.14 | 0.41–3.15 | 0.80 | |||
| TG | 1.01 | 0.99–1.02 | 0.14 | |||
| HDL-C | 0.95 | 0.92–0.99 | 0.007 | 0.98 | 0.94–1.03 | 0.39 |
| LDL-C | 0.99 | 0.98–1.001 | 0.11 | |||
| HbA1c | 0.96 | 0.68–1.01 | 0.11 | |||
| eGFR | 0.96 | 0.93–0.99 | 0.008 | 0.97 | 0.93–1.02 | 0.25 |
Multivariate analysis was performed with the presence of plaque as binary dependent variables and with the log cfDNA, age, male, HDL-C, eGFR as covariates.
Abbreviations: BMI, body mass index; eGFR, estimated glomerular filtration rate; HbA1c, Hemoglobin A1c; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; mt-cfDNA, mitochondrial cell-free DNA; n-cfDNA, nuclear cell-free DNA; TG, Triglyceride.