TABLE 2.
Summary of pharmacokinetic parameters
| Parameter | Ensovibep 225 mg | Ensovibep 600 mg | ||||
|---|---|---|---|---|---|---|
| n | Mean a | CV (%) or SD a | n | Mean a | CV (%) or SD a | |
| AUCinf (h * μg/mL) | 5 b | 37 170 | 18.1 | 6 | 100 068 | 37.9 |
| V D (mL) | 5 b | 2844 | 34.3 | 6 | 2735 | 37.2 |
| CL (mL/h) | 5 b | 6.13 | 1.02 | 6 | 6.39 | 2.81 |
| C max (μg/mL) | 6 | 88.8 | 20.3 | 6 | 233 | 19.3 |
| t 1/2 (h) | 5 b | 326 | 119 | 6 | 303 | 136 |
| T max (h) | 6 | 1.42 | 1.40‐2.70 | 6 | 2.04 | 1.37‐2.68 |
Abbreviations: CV, coefficient of variation; AUCinf, area under the concentration‐time curve from time 0 to infinity; CL, clearance; C max, maximum concentration; t ½, half‐life; T max, time to maximum concentration following start of infusion; V D, apparent volume of distribution.
a
C max and AUCinf are reported as geometric mean and coefficient of variation (%); CL, V D and t 1/2 are reported as arithmetic mean and standard deviation (SD); T max is reported as median (minimum − maximum).
b
t 1/2 could not be accurately estimated in one patient. PK parameters related to t 1/2 estimation (including V D, AUCinf and CL) are not reported for this patient.