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. 2023 Jan 11;12:1044699. doi: 10.3389/fonc.2022.1044699

Figure 6.

Figure 6

YUM70 reduces cell viability and restores cisplatin sensitivity in cisplatin-resistant SCC15. (A) Cisplatin-resistant SCC15 cells (the cisR-3 line) were treated with increasing doses of YUM70 for 48 hr. Cell viability was determined by WST-1 assay. DMSO was used as vehicle control. (B) Representative images of cisR-3 cells treated with the indicated dosages of YUM70 alone or in combination with 12 μM cisplatin for 48 hr. Scale bar = 100 μm. (C) Western blot of lysates of cisR-3 cells treated with the indicated dosages of YUM70 for 48 hr, alone or in combination with 12 μM cisplatin. The protein levels of cleaved Caspase 7 (c-Cas7) and cleaved-PARP (c-PARP) were measured, with GAPDH serving as loading control. (D) Cell viability of cisR-3 cells treated with the indicated dosages of YUM70, alone or in combination with the indicated dosages of cisplatin for 48 hr was measured by WST-1 assay. Data are presented as means ± S.D. (n=3).