FIGURE 4.

Upregulation of interferon-regulated pathways and proteins in fully differentiated primary human bronchial epithelial cells (phBECs) independent of disease state post-influenza virus infection. (A) Pathway analysis performed using the tool PANTHER and all 290 differentially expressed proteins post-infection, independent of disease state and taking account of both time points. (B–G) Box plots of interferon-regulated proteins depicting the median (middle horizontal line), the 25 and 75% percentile (lower and upper edge of the box), and the range between largest and smallest value up to a maximum of 1.5 × interquartile range (vertical lines). Data points beyond that range are regarded as outliers and are shown as individual points. IRF9, interferon-regulatory factor 9; MX1, Interferon-induced GTP-binding protein Mx1; OAS1, 2’–5’-oligoadenylate synthase 1; STAT1, signal transducer and activator of transcription 1-α/β; ISG15, ubiquitin-like protein ISG15; IFIT1, interferon-induced protein with tetratricopeptide repeats 1.