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. Author manuscript; available in PMC: 2023 Jan 25.
Published in final edited form as: Int Rev Neurobiol. 2019 Nov 1;148:305–343. doi: 10.1016/bs.irn.2019.10.018

Fig. 5.

Fig. 5

Different microglial responses to alcohol based on age in the modified Majchrowicz Rat model: Iba-1 was expressed throughout the hippocampus. Representative photomicrographs of the dentate gyrus show that Iba-1 was present in the young (A) and aged control animals (C), but that in the young animals ethanol increased the microglial response (B). However, ethanol’s effects on microglia were not present in the aged group (D). Quantification of the subregions indicated that ethanol only increased Iba-1 immunoreactivity in the DG (E) and CA1 (F) of the young animals. No effect of ethanol or age was observed on Iba-1 immunoreactivity in the CA2/3 region (G). *P < 0.05 compared to control treatment. Scale bar= 150 μm.